Waves of airstrikes in Israel and Iran as exchange of fire enters second night

The Israeli Air Force is currently striking Tehran, according to the IDF.

The IDF said they're hitting "military targets" in the city.

Iran launched missiles toward Israel "a short while ago," according to the IDF.

"Defensive systems are operating to intercept the threat," the IDF said, instructing members of the public to go into a protected space if they receive an alert.

Sirens could be heard in northern Israel, according to NBC News journalists on the ground. Heavy bombing could be heard in Haifa.

A large mock-up of Jerusalem’s Dome of the Rock Shrine stood in Tehran's Enghelab (Revolution) Square during a rally today, when some gathered in solidarity with the government against Israel’s attacks on Iran.

The rally also marked Eid al-Ghadir, when, according to Shiite Muslim belief, the Islamic prophet Muhammad designated his nephew and companion Ali ibn Abi Talib as his successor.

European Union's High Representative for Foreign Affairs Kaja Kallas called on Israel and Iran "to abide by international law, show restraint and refrain from taking further steps which could lead to serious consequences such as potential radioactive release."

In the statement, Kallas reiterated the E.U.'s position that Iran should never be allowed to acquire nuclear weapons.

"The EU will continue to contribute to all diplomatic efforts to reduce tensions and to find a lasting solution to the Iranian nuclear issue which can only be through a negotiated deal," Kallas said.

President Donald Trump said that Russian President Vladimir Putin called him today to wish him a happy birthday and discuss the escalating conflict between Israel and Iran.

"The call lasted approximately 1 hour," Trump wrote in a post on Truth Social. "He feels, as do I, this war in Israel-Iran should end, to which I explained, his war should also end."

Trump said they also discussed the war between Russia and Ukraine, adding that Putin "is doing the planned prisoner swaps — large numbers of prisoners are being exchanged, immediately, from both sides."

He did not give an exact time frame for the exchange, but mentioned he would discuss the conflict between the two countries with Putin next week.

Israel has been striking Iran for nearly 40 hours straight in what it says is an effort to target the country's nuclear program, according to the IDF.

"Our air forces are completing a wave of strikes targeting the nuclear program at the heart of Iran," IDF spokesperson Effie Defrin said. "We destroyed the underground site in western Iran where dozens of missiles were stored. Natanz and Isfahan were struck."

The IDF said earlier today it struck an underground site in western Iran that was used to store and launch "surface-to-surface missiles and cruise missiles." The military shared video of what it said was the attack.

Defrin said Israel will "deepen the damage to Iran’s nuclear program," and that Tehran was yesterday's focus because it "is no longer immune."

"Alongside the operation in Iran, IDF forces and systems are deployed across all arenas of conflict, both in defense and offense, prepared for various developments and ready to protect the state and your security," Defrin said.

Defrin also said that the IDF has reinforced its troops in the West Bank, where it is "conducting offensive operations while also strengthening the defense of various communities and the security barrier."

Four critical buildings were damaged by Israeli airstrikes at a nuclear site in Isfahan, according to the International Atomic Energy Agency.

This includes the Uranium Conversion Facility and the Fuel Plate Fabrication Plant, the IAEA said.

There has been no increase in off-site radiation levels, the agency said.

In southern Iran, a fire at the South Pars gas refinery has been brought under control after an Israeli airstrike impacted it today, according to Iranian state media, Mehr News.

French President Emmanuel Macron said that he spoke to Iranian President Massoud Pezeshkian today and invited him to "return swiftly to the negotiating table" to discuss their nuclear weapons.

"Iran’s nuclear program is a serious concern and must be resolved through negotiation," Macron wrote on X, adding that France is ready to contribute all efforts to achieve de-escalation between the country and Israel.

Macron also demanded the release of Cécile Kohler and Jacques Paris, a French couple who have been held in Iran for three years, he said. The couple is accused of espionage.

Macron also asked that French nationals in Iran not be targeted "under any circumstances" amid the conflict.

Iranian missiles and Israeli interceptors were visible over Beirut today.

In a telephone conversation with Saudi Arabia’s Crown Prince Mohammed bin Salman, Turkish President Recep Tayyip Erdogan said that Israel under Prime Minister Benjamin Netanyahu is the region's biggest threat to stability and security, according to a Turkish president's office post on X.

Erdogan said that Israel's attack on Iran demonstrates this, and that the country "must be stopped in order to reduce tensions." He also criticized the international community for "turning a blind eye" to Israel's actions in Gaza, which has brought the country "to this lawless and aggressive point."

Erdogan stressed that the region can't handle "a new crisis," adding that "the nuclear dispute could only be resolved by continuing negotiations."

Israel targeted residential neighborhoods and civilian infrastructure, killing 60 people, including 29 children, according to foreign ministry spokesman Esmaeil Baqaei.

"These actions constitute a serious and unambiguous violation of international law and the Charter of the United Nations," Baqaei said on X.

Israel's massive attack on Iran yesterday marked a dramatic escalation in tensions between the countries, sparking concern that this could escalate into a regional war. Iran vowed to retaliate, and did last night.

Leader of the Houthis Abdul-Malik al-Houthi pledged the group's support to Iran following Israel's attack. "We in Yemen support Iran's response and stand as partners in this position with all our capabilities," al-Houthi said.

In a video address to Iranian people yesterday, Israeli Prime Minister Benjamin Netanyahu said his fight is not against them, but against the Islamic regime.

Satellite views show the Natanz nuclear enrichment facility, approximately 135 miles southeast of Tehran, on Jan. 14 and today. Multiple buildings were destroyed in Israeli airstrikes.

During remarks today, Israeli Prime Minister Benjamin Netanyahu said the country's air force will retaliate against Iran in the very near future.

Iran retaliated to a massive attack from Israel yesterday that killed at least 100 people, Iranian officials said. Iran's retaliatory attack killed three people in Israel, Netanyahu confirmed.

"In the very near future, you’ll see the Israeli Air Force — our pilots — flying over the skies of Tehran," Netanyahu said. "We will strike every site and every target of the Ayatollah regime."

Netanyahu said what the Iranians "felt so far is nothing compared to what they will feel under the full force of our arm in the coming days." He added that world leaders have expressed "tremendous admiration" toward Israel.

"We are in a fateful campaign for our very existence," he said. "We will fight until we achieve victory."

A banner hanging in Tehran today bears messages in Farsi and Hebrew calling for revenge against Israel for its strikes on Iranian sites.

Posters featuring images of Iranian nuclear scientists and senior military commanders killed in Israeli attacks hang on the streets of Tehran today.

Retaliatory strikes carried out by the Iranian military resulted in the destruction of numerous buildings and vehicles.

Iran is pondering whether to close the Strait of Hormuz, a key shipping lane to the Persian Gulf, according to Iran's state run media.

Esmail Kowsawi, a member of Iran's National Security Commission in Parliament, said Iran will make a decision "when appropriate," according to the report.

The Strait of Hormuz connects the Persian Gulf to the Arabian Sea. Roughly 20 million barrels of oil pass through per day, amounting to about one-fifth of global oil shipments — more than any other chokepoint besides the Strait of Malacca at the entrance of the South China Sea.

Iran has informed the U.S., France and the U.K. that it will attack the bases of countries supporting Israel, including by intercepting Iranian strikes on Israel, according to Iranian state media.

IRINN reported today that "any country that assists in intercepting Iranian strikes on Israel will be considered a co-belligerent, and all its regional bases, including military installations in the Persian Gulf states, as well as naval vessels in the Persian Gulf and Red Sea, will be targeted by Iranian forces."

Earlier today, Farsnews, an Iranian news agency affiliated with the Islamic Revolutionary Guard Corps, said Iranian attacks will spread across “all occupied lands” and American bases in the region.

Israel killed three nuclear scientists during its attacks on the country, Iranian state media reported today.

The scientists were identified as Ali Bakaei Karimi, Mansour Asgari and Saeid Borji.

Earlier today, the IDF said that it had killed nine "senior scientists and experts in the Iranian nuclear project."

The IDF list included the names of the three men reported dead by state media.

A White House official tells NBC News that President Donald Trump will be monitoring the situation between Israel and Iran and developments across the Middle East all day before going to the military parade this evening.

A spokesperson for Iran’s Ministry of Foreign Affairs says talks between the U.S. and Iran that were scheduled for Sunday have been cancelled, following Israel’s attack on the country yesterday.

The two nations were set to meet in Muscat, Oman, for a sixth round of talks over Tehran’s nuclear program.

“The United States has supported the Zionist regime’s aggression, including the targeting of Iran’s peaceful nuclear facilities,” Esmaeil Baghaei said Saturday, according to Iranian state media Mehr News.

“Participating in talks with a party that is the principal supporter and accomplice of the aggressor is fundamentally meaningless.”

The U.S. has not confirmed whether or not the talks are set to go ahead.

Israel’s military strikes on Iran have struck at the heart of the country’s military leadership and nuclear program, creating a possible vacuum at the top of the regime that could hinder its ability to recover from the onslaught, experts say.

But — assuming that it still can — there is a scenario in which the strikes could lead Tehran to abandon negotiations over its nuclear program and instead rush toward building a bomb, according to analysts and former U.S. officials.

The killing of top Iranian military officers as well as several nuclear scientists will likely have sparked fears in Tehran that Israeli intelligence had deeply penetrated the regime and that other senior figures could also be in danger.

Israel has previously pulled off brazen assassinations inside Iran, targeting senior government scientists involved in the country’s nuclear program and the political leader of the Iranian-backed Palestinian group Hamas when he was visiting Tehran.

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Iran's Esfahan nuclear facilities have shown no increase in off-site radiation levels after they were targeted by Israeli air strikes yesterday, according to the International Atomic Agency.

The Israeli military launched a blistering attack on Iran's nuclear and army sites, killing some of the country's top military leaders and senior scientists. Israel said it had struck the nuclear research facility in Esfahan, as well as Iran’s main nuclear enrichment facility in Natanz.

“The IAEA remains in close contact with Iran,” it said in a post on X.

U.N. nuclear chief Rafael Grossi told the Security Council that the above-ground section of the Natanz facility was destroyed, but the main centrifuge facility underground did not appear to have been hit, according to the Associated Press.

The attacks have cast doubt on a sixth round of talks between the U.S. and Iran on Sunday. On Friday, Iran's Foreign Ministry called the discussions "meaningless" after earlier accusing the U.S. of complicity in the attacks.

Israel’s first assessments are emerging. It believes Iran’s nuclear program has been badly damaged. It is not destroyed.

"Our initial assessment is that we have been able to damage both Isfahan and Natanz" nuclear sites, an Israeli military official said this morning. Natanz nuclear complex is Iran’s main uranium enrichment facility, and the official said the damage there is "significant."

"According to our initial understanding and what we have seen from our operations it will take much more than a few weeks to repair what happened in Natanz and Isfahan," the official said.

Yesterday, the U.N. nuclear watchdog chief Rafael Grossi told the Security Council that a Natanz enrichment site had been destroyed along with it’s electricity infrastructure. He also said centrifuges may have been damaged. Israel also says it has killed 9 senior nuclear researchers, who were driving forward Iran's nuclear program.

But the Israeli military official said another nuclear site, Fordow, which has an enrichment plant buried deep underground, has not yet been struck. Before this Israeli campaign experts believed that the only way to destroy Fordow was with a massive ordnance penetrator that only America has: a 30,000 pound bomb that would be dropped from a B-2 bomber.

Asked by NBC News whether Fordow could be destroyed without U.S. assistance the Israeli official said, "I don’t want to go into specifics about what that would look like, if we did" target Fordow, "I want to leave that unanswered at the moment."

The Associated Press reported earlier today that Israel had appeared to strike Fordow, citing an Iranian news outlet close to the government that reported hearing explosions nearby.

Pope Leo XIV has appealed for peace between Israel and Iran, urging its leaders to seek de-escalation through diplomacy and respect. 

“The commitment to building a safer world, free from the nuclear threat, must be pursued through respectful encounters and sincere dialogue to build a lasting peace, founded on justice, fraternity, and the common good,” he said in a statement.  

“No one should ever threaten another’s existence. It is the duty of all countries to support the cause of peace, initiating paths of reconciliation and promoting solutions that guarantee security and dignity for all.”

An Israeli military official said “difficult days” lie ahead for Israel, but that the country attacked Iran through “existential necessity.”

The Israeli military launched a massive attack on Iran on Friday in a dramatic escalation of their long-running conflict that drew retaliatory missile assaults from Tehran and raised the risk of another war in the Middle East.

"We understood when we entered this operation that it might be difficult, that there are difficult days ahead of us, complex days ahead of us, why we woke up the Israeli population and gave them warnings and time to rearrange their safe room and and get ready, because we understand who we’re facing," the official said this morning.

The official also denied Iranian reports that they had downed Israeli planes and taken an Israeli pilot hostage, saying all jets had returned safely.

“Last night and this morning, all aircrafts and all pilots and members of the plane, co pilots, navigators, whatever be, all returned safely,” he said.

Iran has confirmed that two more high-ranking generals have been killed by Israeli strikes.

Sardar Sarshakar Pasdar Mehdi Rabbani, Deputy Chief of Operations of the Armed Forces, and Sardar Sarshakar Gholamreza Mehrabi, Deputy Intelligence Chief of Staff of the Armed Forces, were announced dead today.

Yesterday, Iran announced the death of six other senior military officials.

Israeli Defense Minister Israel Katz said Saturday that Iran's capital city Tehran "will burn" if the country continues to strike Israel with missiles.

In a statement addressing Iran’s Supreme Leader Ayatollah Ali Khamenei, Katz said Iranian citizens “and in particular the residents of Tehran, will pay a heavy price for the criminal harm to the citizens of Israel.”

“If Khamenei continues to fire missiles at the Israeli home front," Katz added. "Tehran will burn.”

Iran said the dialogue with the U.S. over Tehran’s nuclear program is “meaningless,” but said it is yet to decide on whether to attend planned talks on Sunday.

“The other side (the U.S.) acted in a way that makes dialogue meaningless. You cannot claim to negotiate and at the same time divide work by allowing the Zionist regime (Israel) to target Iran’s territory,” state media on Saturday quoted foreign ministry spokesperson Esmaeil Baghaei as saying.

“It is still unclear what decision we will make on Sunday in this regard.” 

Iran earlier accused the U.S. of being complicit in Israel’s attacks, but Washington denied the allegation. President Trump told Reuters that he and his team had known the Israeli attacks were coming but they still saw room for an accord.

Iran had no choice but to retaliate against Israel’s sweeping strikes on its nuclear facilities and targeted killings of senior officials, experts of the region said Friday, risking an escalation that could drag the United States into a spiraling conflict.

Late on Friday, loud blasts were heard throughout Israel and the public was told to take shelter after the military said it identified missiles being launched from Iran. Iran launched “hundreds of ballistic missiles,” Iran’s Islamic Republic News Agency reported, adding that “the hard retaliation has begun.”

While not a surprise, Israel’s earlier attack was remarkable in its severity, with some 200 Israeli fighter jets hitting one of Iran’s main uranium enrichment sites; striking the capital, Tehran; and killing many top military leaders. Israeli Prime Minister Benjamin Netanyahu has vowed more was to come.

This left the Islamic Republic with few options, having been weakened by a succession of Israeli strikes over the past year, experts warn.

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Israeli strikes on Shahid Chamran residential complex in Tehran today have killed an estimated 60 people, 20 of them children, according to a TV report on IRNN, Iran's state-run news agency.

The 14-floor building in Nobonyad Square, north Tehran, is a residential complex for the defense ministry.

Israeli strikes have killed at least 130 people in Tehran, after 78 people were killed yesterday, according to state media reports. Other cities have also reported casualties. No official numbers have been released.

Another round of loud explosions are currently being heard in Tabriz.

Iranian attacks will spread across “all occupied lands” and American bases in the region, according to Farsnews, an Iranian news agency affiliated with the Islamic Revolutionary Guard Corp.

It said the attacks would extend over the next few days, and “will be regretful and painful for the aggressors.”

Iran’s retaliatory strikes on Israel have killed at least three people from Friday into Saturday morning.

A woman and a man were killed by strikes near homes in the city of Rishon in central Israel, according to the the nation’s Magen David Adom emergency services.

A spokesperson from Beilinson Hospital said a woman that was injured critically yesterday was pronounced dead this morning.

Iran’s U.N. ambassador said 78 people were killed and more than 320 wounded by Israeli strikes.

Across central Israel, Iranian missiles have killed three people, damaged homes and injured dozens as strikes continued through Friday night into Saturday morning.

Sheba hospital said 68 people were treated fior various shrapnel injuries and anxiety. Beilinson hospital said 19 injured people had been admitted so far, including seven in light to moderate condition from this morning’s latest barrage of missiles.

Israel’s fire and rescue services said it operated at dozens of sites overnight responding to burning buildings, and Israel’s emergency services Magen David Adom posted pictures on social media of buildings that had collapsed, with paramedics treating people in serious and critical condition

Civilian life is under heavy disruption, with transport hubs closed, including Ben Gurion international airport, and public events suspended. The IDF and MDA have asked Israelis to remain near shelters.

Israel launched an overnight strike on Tehran’s Mehrabad airport, targeting a hangar housing fighting jets, according to Iran’s state media.

The report said a fighter jet base had been hit, but that the runway and main buildings were still intact.

The United States’ ambassador to Israel Mike Huckabee said this morning local time that he has had to shelter five times overnight as Iran has launched missiles at Israel in response to Israel’s attack on the country.

“Been rough nite in Israel. Had to head to shelter 5 times during the nite. It’s now Shabbat here. Should be quiet. Probably won’t be. Entire nation under orders to stay near shelter,” Huckabee wrote on X.

A rocket strike in Israel has injured 21 people, one of whom was in critical condition and several others in serious condition, the Israeli paramedic organization Magen David Adom said. The explosion was in Rishon Lezion.

“Update to rocket strike site in Coastal plain: MDA EMTs and paramedics treating and evacuating 21 patients, one in critical condition, several seriously injured and others in mild to moderate condition,” it said on X.

Initially, 13 had been reported injured while searches were ongoing, and at that time a post on X by Magen David Adom showed showed a collapsed building and other damage. The number of injured was later updated to 21.

UN Secretary-General António Guterres today again called for an end to the escalation after Israel struck Iran with airstrikes and Iran responded with barrages of missiles.

“Enough escalation. Time to stop,” he wrote on X. “Peace and diplomacy must prevail.”