A Canadian math prodigy is accused of stealing over $65 million through complex exploits on decentralized finance platforms and is currently a fugitive from U.S. authorities. Despite facing criminal charges for fraud and money laundering, he has evaded capture by moving internationally, embracing the controversial "Code is Law" philosophy, and maintaining that his actions were legal under the platforms' open-source rules. The Globe and Mail reports: Andean Medjedovic was 18 years old when he made a decision that would irrevocably alter the course of his life. In the fall of 2021, shortly after completing a master's degree at the University of Waterloo, the math prodigy and cryptocurrency trader from Hamilton had conducted a complex series of transactions designed to exploit a vulnerability in the code of a decentralized finance platform. The maneuver had allegedly allowed him to siphon approximately $16.5-million in digital tokens out of two liquidity pools operated by the platform, Indexed Finance, according to a U.S. court document.

Indexed Finance's leaders traced the attack back to Mr. Medjedovic, and made him an offer: Return 90 per cent of the funds, keep the rest as a so-called "bug bounty" -- a reward for having identified an error in the code -- and all would be forgiven. Mr. Medjedovic would then be free to launch his career as a white hat, or ethical, hacker. Mr. Medjedovic didn't take the deal. His social media posts hinted, without overtly stating, that he believed that because he had operated within the confines of the code, he was entitled to the funds -- a controversial philosophy in the world of decentralized finance known as "Code is Law." But instead of testing that argument in court, Mr. Medjedovic went into hiding. By the time authorities arrived on a quiet residential street in Hamilton to search his parents' townhouse less than two months later, Mr. Medjedovic had moved out, taking his electronic devices with him.

Then, roughly two years later, he struck again, netting an even larger sum -- approximately $48.4-million -- by conducting a similar exploit on another decentralized finance platform, U.S. authorities allege. Mr. Medjedovic, now 22, faces five criminal charges -- including wire fraud, attempted extortion and money laundering -- according to a U.S. federal court document that was unsealed earlier this year. If convicted, he could be facing decades in prison. First, authorities will have to find him.

A new study projects that CT scans conducted in 2023 may result in around 103,000 future cancer cases in the U.S. due to low-dose ionizing radiation. "[I]t would put CT scans on par with other significant risk factors for cancer, like alcohol consumption, at least at a population level," reports ScienceAlert. From the report: At an individual level, the theoretical chance of developing cancer from a CT scan is thought to be very minimal, if it exists at all, and patients should not be scared of undergoing these tests if they are deemed medically necessary. However, the number of CT examinations performed each year in the US has increased by more than 30 percent since 2007, and researchers suggest that unwarranted tests are exposing the population to unnecessary radiation. [...]

The anonymous data comes from 143 hospitals and outpatient facilities across the US, catalogued in the UCSF International CT Dose Registry. Using statistics from 2016 to 2022, researchers predicted 93 million CT examinations were carried out in 2023, on roughly 62 million patients. Based on the associated radiation risks, the team estimates that CT scans in 2023 may be tied to 103,000 future cancers. The findings have been published in JAMA Internal Medicine.

Blue Origin's New Shepard completed its 31st mission Monday morning, carrying the first all-female crew to space since Soviet cosmonaut Valentina Tereshkova's 1963 solo flight. The NS-31 mission lifted off from West Texas at 9:30 a.m. EDT, with hundreds of thousands watching via livestream as the autonomous vehicle crossed the Karman line 62 miles above Earth.

The 10-minute suborbital journey carried six passengers: journalist and Bezos' fiancee Lauren SÃnchez, former NASA scientist Aisha Bowe, bioastronautics researcher Amanda Nguyen, CBS journalist Gayle King, pop star Katy Perry, and film producer Kerianne Flynn. Bowe conducted three research experiments during the flight, while Nguyen became the first Vietnamese and Southeast Asian woman in space. The fully reusable New Shepard system features a pressurized capsule that separates from its booster before returning to Earth with three parachutes.

"More than three million children around the world are thought to have died in 2022 as a result of infections that are resistant to antibiotics," reports the BBC, citing a study by two leading experts in child health that used data from sources including the World Health Organization and the World Bank: Experts say this new study highlights a more than tenfold increase in AMR-related infections in children in just three years. The number could have been made worse by the impact of the Covid pandemic...

The report's lead authors, Doctor Yanhong Jessika Hu of Murdoch Children's Research Institute in Australia and Professor Herb Harwell of the Clinton Health Access Initiative, point to a significant growth in the use of antibiotics that are meant to only be held back for the most serious infections. Between 2019 and 2021 the use of "watch antibiotics", drugs with a high risk of resistance, increased by 160% in South East Asia and 126% in Africa. Over the same period, "reserve antibiotics" — last-resort treatments for severe, multidrug-resistant infections — rose by 45% in South East Asia and 125% in Africa.

The authors warn that if bacteria develop resistance to these antibiotics, there will be few, if any, alternatives for treating multidrug-resistant infections.
"Antibiotics are ubiquitous around us," Professor Harwell warns in the article. "They end up in our food and the environment and so coming up with a single solution is not easy." The article also quotes a senior lecturer in microbiology at King's College London, who says the new study "marks a significant and alarming increase compared to previous data".

"These findings should serve as a wake-up call for global health leaders. Without decisive action, AMR could undermine decades of progress in child health, particularly in the world's most vulnerable regions."

Thanks to Slashdot reader Bruce66423 for sharing the article.

"Can you help me take down the Texas lottery?"

That's what a London banker-turned-bookmaker asked "acquaintances" in 2023, reports the Wall Street Journal. The plan was to buy "nearly every possible number in a coming drawing" — purchasing $1 tickets for 25.8 million possible combinations, since "The jackpot was heading to $95 million. If nobody else also picked the winning numbers, the profit would be nearly $60 million." Marantelli flew to the U.S. with a few trusted lieutenants. They set up shop in a defunct dentist's office, a warehouse and two other spots in Texas. The crew worked out a way to get official ticket-printing terminals. Trucks hauled in dozens of them and reams of paper... [Then Texas announced no winner in an earlier lottery, rolling its jackpot into another drawing three days later.] The machines — manned by a disparate bunch of associates and some of their children — screeched away nearly around the clock, spitting out 100 or more tickets every second. Texas politicians later likened the operation to a sweatshop.

Trying to pull off the gambit required deep pockets and a knack for staying under the radar — both hallmarks of the secretive Tasmanian gambler who bankrolled the operation. Born Zeljko Ranogajec, he was nicknamed "the Joker" for his ability to pull off capers at far-flung casinos and racetracks. Adding to his mystique, he changed his name to John Wilson several decades ago. Among some associates, though, he still goes by Zeljko, or Z. Over the years, Ranogajec and his partners have won hundreds of millions of dollars by applying Wall Street-style analytics to betting opportunities around the world. Like card counters at a blackjack table, they use data and math to hunt for situations ripe for flipping the house edge in their favor. Then they throw piles of money at it, betting an estimated $10 billion annually.

The Texas lottery play, one of their most ambitious operations ever, paid off spectacularly with a $57.8 million jackpot win. That, in turn, spilled their activities into public view and sparked a Texas-size uproar about whether other lotto players — and indeed the entire state — had been hoodwinked. Early this month, the state's lieutenant governor, Dan Patrick, called the crew's win "the biggest theft from the people of Texas in the history of Texas." In response to written questions addressed to Marantelli and Ranogajec, Glenn Gelband, a New Jersey lawyer who represents the limited partnership that claimed the Texas prize, said "all applicable laws, rules and regulations were followed...."

Lottery officials and state lawmakers have taken steps to prevent a repeat.
The article also looks at a group of Princeton University graduates calling themselves Black Swan Capital that's "won millions in recent years" by targetting state lottery drawings with unusually favorable odds.

"State lottery directors say they are seeing more organized efforts to buy lottery tickets in bulk," according to the article, "but that the groups are largely operating legally and transparently..."

"Researchers say that a person's intelligence plays a bigger role in their computer proficiency than previously believed," writes SciTechDaily, "so much so that practice alone may not be enough to ensure ease of use."

A new study has found that general cognitive abilities, such as perception, reasoning, and memory, are more important than previously believed in determining a person's ability to perform everyday tasks on a computer... "It is clear that differences between individuals cannot be eliminated simply by means of training," says Antti Oulasvirta [a professor at Finland's Aalto University who conducted extensive human-computer interaction research with his team and the University of Helsinki Department of Psychology]. "In the future, user interfaces need to be streamlined for simpler use. This age-old goal has been forgotten at some point, and awkwardly designed interfaces have become a driver for the digital divide.

"We cannot promote a deeper and more equal use of computers in society unless we solve this basic problem," Oulasvirta says...

This is the first-ever study to measure users' actual ability to perform daily tasks on a PC, as previous studies have relied on participants self-assessing their abilities via questionnaires... "The study revealed that, in particular, working memory, attention, and executive functions stand out as the key abilities. When using a computer, you must determine the order in which things are done and keep in mind what has already been done. A purely mathematical or logical ability does not help in the same way," says university lecturer Viljami Salmela [from the University of Helsinki].
"Our results suggest that contemporary user interfaces are getting so complex that their design is starting to affect inclusivity," their paper concludes, saying that it ultimately raises a question. "How can we design user interfaces to decrease the role of cognitive abilities."

Black holes "often exhibit long periods of dormancy," writes Popular Science, adding that astronomers had never witnessed a black hole "wake up" in real time. "Until now..."

In February of 2024 X-ray bursts were spotted coming out of a black hole named Ansky by Lorena Hernández-García at Chile's Valparaiso University, according to the article. And what astronomers have now seen "challenges prevailing theories about black hole lifecycles." Hernández-García and collaborators then determined the black hole was displaying a phenomenon known as a quasiperiodic eruption, or QPE [a short-lived flaring event...] While a black hole inevitably destroys everything it captures, objects behave differently during their impending demise. A star, for example, generally stretches apart into a bright, hot, fast-spinning disc known as an accretion disc. Most astronomers have theorized that black holes generate QPEs when a comparatively small object like a star or even a smaller black hole collides with an accretion disc. In the case of Ansky, however, there isn't any evidence linking it to the death of a star.

"The bursts of X-rays from Ansky are ten times longer and ten times more luminous than what we see from a typical QPE," said MIT PhD student and study co-author Joheen Chakraborty. "Each of these eruptions is releasing a hundred times more energy than we have seen elsewhere. Ansky's eruptions also show the longest cadence ever observed, of about 4.5 days." Astronomers must now consider other explanations for Ansky's remarkable behavior. One theory posits that the accretion disc could come from nearby galactic gas pulled in by the black hole instead of a star. If true, then the X-rays may originate from high energy shocks to the disc caused by a small cosmic object repeatedly passing through and disrupting orbital matter.
It's detailed in a study published on April 11 in Nature Astronomy....

Meanwhile, scientists "have uncovered the strongest evidence yet for the existence of elusive intermediate-mass black holes," reports SciTechDaily.

And there's more black hole news from RockDoctor (Slashdot reader #15,477): Given the recent work on galaxy-centre Super-Massive Black Holes (SMBHs), you may be surprised to learn that the only Stellar-Mass Black Holes (SMBHs ... uh, "BHs") identified to-date have been by their gravitational waves, as they merge with another BH or a neutron star. But the long-running OGLE (Optical Gravitational Lensing Experiment) project (1992 — present) has recently confirmed that it has detected an isolated BH not orbiting another bright object, or "swallowing" much of anything...

In this case, 16 other telescopes performed sensitive astrometry (position measurement) over 11 years including the Hubble Space Telescope (HST). These multiple measurements plot an ellipse on the sky, mirroring the movement of the Earth around it's orbit — parallax. Which means this is a relatively close object (1520 parsecs / ~5000 light years).... And there is no sign of a third light emitting body nearby, which means this is an isolated black hole, not orbiting any other body (or, indeed, with any other [small] star orbiting it).

Abstract of a paper on NBER: There is much disagreement about the extent to which financial incentives motivate study participants. We elicit preferences for being paid for completing a survey, including a one-in-twenty chance of winning a $100 electronic gift card, a guaranteed electronic gift card with the same expected value, and an option to refuse payment. More than twice as many participants chose the lottery as chose the guaranteed payment. Given that most people are risk averse, this pattern suggests that factors beyond risk preferences -- such as hassle costs -- influenced their decision-making. Almost 20 percent of participants actively refused payment, demonstrating low monetary motivation. We find both systematic and unobserved heterogeneity in the characteristics of who turned down payment. The propensity to refuse payment is more than four times as large among individuals 50 and older compared to younger individuals, suggesting a tradeoff between financially motivating participants and obtaining a representative sample. Overall, our results suggest that modest electronic gift card payments violate key requirements of Vernon Smith's induced value theory.

Germany will get a new "super-high-tech ministry" responsible for research, technology, and aerospace, according to the coalition agreement published by the incoming government this week. From a report: The announcement is one of several nods to science in the 144-page agreement, unveiled on 9 April following weeks of negotiations between the center-right Christian Democrats (CDU) and its sister party, the Christian Social Union in Bavaria (CSU) -- who together won the most seats in February's federal elections -- and the center-left Social Democrats. The agreement is expected to be formally approved by the three parties by early May, paving the way for CDU leader Friedrich Merz to be elected chancellor.

[...] The new agreement lists a number of scientific priorities for the new government, including support for artificial intelligence, quantum technologies, biotechnology, microchip development and production, and fusion energy. "Our goal is that the world's first fusion reactor should be realized in Germany," the text states. It also mentions personalized medicine, oceans research, and sustainability research as "strategic" areas. But the agreement does not include any budget estimates, and observers caution it is unclear where the money for new programs would come from. The agreement does affirm current commitments to increase the budgets of the country's main research organizations by 3% per year through 2030.

The Food and Drug Administration says it would begin phasing out animal testing requirements for antibody therapies and other drugs and move toward AI-based models and other tools it deems "human-relevant." Axios: The FDA said it would launch a pilot program over the next year allowing select developers of monoclonal antibodies to use a primarily non-animal-based testing strategy. Commissioner Marty Makary in a statement said the shift would improve drug safety, lower research and development costs and address ethical concerns about animal experimentation.

Scientists have recreated in a laboratory the sensory pathway that transmits feelings of pain to the human brain, in a breakthrough that could lead to better treatments. Financial Times: A team at Stanford University in California is the first to combine different neurons grown from human stem cells into a functioning brain circuit in a lab dish. Their experiments, published in Nature on Wednesday, illustrate scientists' rapid progress in replicating living tissues and organs through synthetic biology.

When the Stanford scientists exposed the brain circuit they had created to sensory stimulants, they observed waves of electrical activity travelling along it. The molecule that makes chilli peppers hot, capsaicin, immediately induced a strong response.

[...] The synthetic brain circuits could be used to screen for better-targeted therapies for pain that tone down excessive waves of neurotransmission, without affecting the brain's reward circuitry as opioids do, project leader [Sergiu] Pasca said. The assembloids themselves cannot be said to "feel pain," he emphasised: "They transmit nervous signals that are processed by a second pathway going deeper into the brain and giving us the aversive, emotional component of pain."

New research suggests that given the right kind of training, AI bots can deliver mental health therapy with as much efficacy as -- or more than -- human clinicians. From a report: The recent study, published in the New England Journal of Medicine, shows results from the first randomized clinical trial for AI therapy. Researchers from Dartmouth College built the bot as a way of taking a new approach to a longstanding problem: The U.S. continues to grapple with an acute shortage of mental health providers. "I think one of the things that doesn't scale well is humans," says Nick Jacobson, a clinical psychologist who was part of this research team. For every 340 people in the U.S., there is just one mental health clinician, according to some estimates.

While many AI bots already on the market claim to offer mental health care, some have dubious results or have even led people to self-harm. More than five years ago, Jacobson and his colleagues began training their AI bot in clinical best practices. The project, says Jacobson, involved much trial and error before it led to quality outcomes. "The effects that we see strongly mirror what you would see in the best evidence-based trials of psychotherapy," says Jacobson. He says these results were comparable to "studies with folks given a gold standard dose of the best treatment we have available."

Colossal Biosciences has claimed it "successfully restored" the extinct dire wolf after a "10,000+ year absence," but scientists clarify these are actually genetically modified grey wolves. The U.S. company announced three pups -- males Remus and Romulus born in October, and female Khaleesi born in January -- as dire wolves, but made only 20 genetic edits to grey wolves.

Beth Shapiro of Colossal told New Scientist that just 15 modifications were based on dire wolf DNA, primarily targeting size, musculature and ear shape. Five other changes involve mutations known to produce light coats in grey wolves. A 2021 DNA study revealed dire wolves and grey wolves last shared a common ancestor about 6 million years ago, with jackals and African wild dogs more closely related to grey wolves.

The internet's physical mass remains contested among scientists, with estimates ranging from a strawberry to something almost unimaginably small. In 2006, Harvard physicist Russell Seitz calculated the internet weighed roughly 50 grams based on server energy, a figure that would now equate to potato-weight given internet growth.

Christopher White, president of NEC Laboratories America, has dismissed this calculation as "just wrong." White suggests a more accurate method that accounts for the energy needed to encode all internet data in one place, yielding approximately 53 quadrillionths of a gram at room temperature. Alternatively, if the internet's projected 175 zettabytes of data were stored in DNA -- a storage medium scientists are actively exploring -- it would weigh 960,947 grams, equivalent to 10.6 American males. Though scientists debate measurement methods, White asserts the web's true complexity makes it "essentially unknowable."

Scientists "demonstrated a promising step toward using a person's own immune cells to fight gastrointestinal cancers" at America's National Institutes of Health (or NIH), reports the Washington Post.

But the results were published in Nature Medicine on Tuesday — "the same day the agency was hit with devastating layoffs..." The treatment approach is still early in its development; the personalized immunotherapy regimen shrank tumors in only about a quarter of the patients with colon, rectal and other GI cancers enrolled in a clinical trial. But a researcher who was not involved in the study called the results "remarkable" because they highlight a path to a frustratingly elusive goal in medicine — harnessing a person's own immune defenses to target common solid tumor cancers. Until now, cell-based immunotherapy has worked mainly on blood cancers, such as leukemia, but not the solid cancers that seed tumors in the breast, brain, lungs, pancreas and GI tract...

But the progress arrives at a sad time for science — and for patients, said the leader of the work, NIH immunotherapy pioneer Steven Rosenberg. Two patients' treatments using the experimental therapy had to be delayed because NIH's capacity to make personalized cell therapies has been slowed by the firing of highly skilled staff and by purchasing slowdowns. Those occurred even before major layoffs took place Tuesday... The Department of Health and Human Services (HHS) responded to an email asking about clinical trial delays with a statement: "NIH and HHS are complying with President Trump's executive order."
It's "a very exciting study," said Patrick Hwu, president of the Moffitt Cancer Center in Tampa. Finding ways to tailor this cell-based immunotherapy approach to common solid tumors that cause the vast majority of cancer deaths has remained a major scientific challenge... Rosenberg and colleagues first tried to create tumor infiltrating lymphocytes [or "TILs"] using the method that worked in melanoma for 18 patients with GI cancers that had spread. It failed completely. In a second iteration, his team sequenced the mutations present in each patient's tumor and used that information to sift out and expand the TILs that could home in on that patient's specific tumor cells. The results were far from a triumph, but provided a clue — this time, three of 39 patients' tumors shrank. In the last stage of the trial, the scientists added a drug called pembrolizumab that takes the brakes off immune cells. This time, eight of the 34 patients responded.

"Right now, only a few labs in the country can do what they just did," Hwu said.
While Rosenberg is already working "to refine and improve upon the results," he told the Post that two scientists involved in the specialized process of preparing the cells to treat patients were fired in the probationary purge. "We've had to slow down our work and delay the treatment of some patients...."

And there's also dramatically fewer people now who can purchase research materials, which the Post says it "making it slower and more difficult to obtain supplies."