New general therapy for Autoimmune diseases
October 5, 2024 2:25 PM Subscribe
Nature reports: World-first therapy using donor cells sends autoimmune diseases into remission A new application of CAR-T therapy that doesn't require extraction and modification of the patient's own cells. Using donated cells a "one size fits all" therapy is a possibility.
Derek Lowe of the old "Things I won't work with" blog has more details:
https://www.science.org/content/blog-post/car-t-autoimmune-disorders
As he says in the link: "It's a breakthrough, and no doubt about it."
Derek Lowe of the old "Things I won't work with" blog has more details:
https://www.science.org/content/blog-post/car-t-autoimmune-disorders
As he says in the link: "It's a breakthrough, and no doubt about it."
This is such promising news. I really hope this keeps looking as impressive as it does in the article.
This would be an amazing improvement in so many people's lives.
posted by pattern juggler at 2:32 PM on October 5
This would be an amazing improvement in so many people's lives.
posted by pattern juggler at 2:32 PM on October 5
That's why it caught my eye, severe Crohn's here.
posted by aleph at 2:36 PM on October 5 [3 favorites]
posted by aleph at 2:36 PM on October 5 [3 favorites]
Crohn's is a nightmare.
posted by pattern juggler at 2:54 PM on October 5
posted by pattern juggler at 2:54 PM on October 5
It's several nightmares all galloping together, biting and clawing at each other to go first, to a (not)glorious finish. But recently, it has turned better. Will keep doing what I'm doing and hope for the best.
posted by aleph at 3:03 PM on October 5 [2 favorites]
posted by aleph at 3:03 PM on October 5 [2 favorites]
Hope you continue improving.
posted by pattern juggler at 3:06 PM on October 5
posted by pattern juggler at 3:06 PM on October 5
Me (fervently!) too
posted by aleph at 3:07 PM on October 5 [1 favorite]
posted by aleph at 3:07 PM on October 5 [1 favorite]
Oh, and to add to the anecdata. First symptoms showed up about 7 months after the second, much heavier, round of antibiotics for a nasty bug that was going around the office. The first series didn't work so went right into the nervous-giving-it-to-me series. /anecdata
posted by aleph at 3:19 PM on October 5
posted by aleph at 3:19 PM on October 5
They used the CRISPR–Cas9 gene-editing tool to knock out five genes in the T cells, to prevent both the grafted cells from attacking the host’s body and the host’s immune system from attacking the donor cells.Having gotten my introduction to immunology from Lauren Sompayrac's excellent (but introductory) How the Immune System Works, I am very, very curious to know how you prevent the body's immune system from attacking the donor cell by knocking out genes in the donor cell.
That feels like the kind of thing that the immune system is expressly designed to prevent. What sort of bug did we find in the body's antivirus software to make this possible?
posted by clawsoon at 4:37 PM on October 5
I'm also curious to know if anybody has been working on this for Type I diabetes (or is about to start working on it now).
posted by clawsoon at 4:39 PM on October 5
posted by clawsoon at 4:39 PM on October 5
My understanding is they knocked out genes in the donor cells that express antigens on the cells surface that makes the patients body attack them.
posted by aleph at 5:29 PM on October 5
posted by aleph at 5:29 PM on October 5
The only Type I vaccine I know of is:
https://frederick.cancer.gov/news/study-explores-type-1-diabetes-vaccine
posted by aleph at 5:34 PM on October 5
https://frederick.cancer.gov/news/study-explores-type-1-diabetes-vaccine
posted by aleph at 5:34 PM on October 5
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posted by aleph at 2:30 PM on October 5 [1 favorite]