Research finds people who have more than four coffees a day have 17% lower chance of head and neck cancers. From a report: If the only thing getting you through a mountain of present-wrapping is a mug of tea or coffee, be of good cheer. Researchers have found people who consume those drinks have a slightly lower risk of head and neck cancers. There are about 12,800 new head and neck cancer cases and about 4,100 related deaths in the UK every year, according to Cancer Research UK.

The new study does not prove that tea and coffee are themselves protective against such cancers, but experts say the findings help to shed light on what has been a much debated area with inconsistent results. "While there has been prior research on coffee and tea consumption and reduced risk of cancer, this study highlighted their varying effects with different sub-sites of head and neck cancer including the observation that even decaffeinated coffee had some positive impact," said Dr Yuan-Chin Amy Lee of Huntsman Cancer Institute and the University of Utah School of Medicine, the senior author of the study.

Writing in the journal Cancer, the team report how they analysed data from 14 studies that covered Europe, North America and Latin America. [...] After taking into account factors such as age, sex, daily number of cigarettes smoked, alcohol consumption and fruit and vegetable consumption, the researchers found that people who drink more than four cups of caffeinated coffee a day have a 17% lower chance of developing head and neck cancers overall compared with those who do not drink the beverage. Specifically they found such consumption was associated with reduced odds of cancers of the oral cavity and the oropharynx -- part of the throat just behind the mouth.

A new study finds that polymer-based commercial tea bags release billions of nanoplastics and microplastics when infused. It also shows for the first time that these particles are capable of being absorbed by human intestinal cells, entering the bloodstream, and potentially affecting human health. The study by the Mutagenesis Group of the UAB Department of Genetics and Microbiology has been published in the journal Chemosphere. Medical Xpress reports: The tea bags used for the research were made from the polymers nylon-6, polypropylene and cellulose. The study shows that, when brewing tea, polypropylene releases approximately 1.2 billion particles per milliliter, with an average size of 136.7 nanometers; cellulose releases about 135 million particles per milliliter, with an average size of 244 nanometers; while nylon-6 releases 8.18 million particles per milliliter, with an average size of 138.4 nanometers. To characterize the different types of particles present in the infusion, a set of advanced analytical techniques such as scanning electron microscopy (SEM), transmission electron microscopy (TEM), infrared spectroscopy (ATR-FTIR), dynamic light scattering (DLS), laser Doppler velocimetry (LDV), and nanoparticle tracking analysis (NTA) were used.

The particles were stained and exposed for the first time to different types of human intestinal cells to assess their interaction and possible cellular internalization. The biological interaction experiments showed that mucus-producing intestinal cells had the highest uptake of micro and nanoplastics, with the particles even entering the cell nucleus that houses the genetic material. The result suggests a key role for intestinal mucus in the uptake of these pollutant particles and underscores the need for further research into the effects that chronic exposure can have on human health.

fjo3 shares a report from the Washington Post: The International Space Station had to fire thrusters from a docked spacecraft last month to avoid a piece of debris that has been circling the globe for the nearly 18 years since the Chinese government blasted apart one of its own satellites in a weapons test. The evasive maneuver was the second in just six days for the space station, which has four NASA astronauts and three Russian cosmonauts aboard. That is the shortest interval ever between such actions, illustrating the slowly worsening problem of space junk in orbit. Debris is an increasingly vexing issue not only for NASA, but also for companies such as SpaceX and OneWeb seeking to protect the thousands of small satellites they send into space to provide high-speed internet. The debris cloud from China's 2007 destruction of the Fengyun 1C satellite remains one of the most persistent threats in orbit, with about 3,500 fragments still posing collision risks to spacecraft. Since 2020, the ISS has performed 15 debris-avoidance maneuvers.

The evasive maneuver was performed after a Space Force warning. According to the report, Space Force now tracks over 47,200 objects in orbit, issuing approximately 23 daily collision warnings -- up from just six per day five years ago.

An anonymous reader shared this report from Health magazine: "Most people think of aging as occurring gradually, constantly, and linearly," senior study author Michael Snyder, PhD, a professor of genetics and director of the Center for Genomics and Personalized Medicine at Stanford University, told Health. But "we're not just changing gradually over time; there are some really dramatic changes," Snyder said in a news release. "It turns out the mid-40s is a time of dramatic change, as is the early 60s. And that's true no matter what class of molecules you look at."

And these molecular changes aren't insignificant to our health — they were seen in molecules related to cardiovascular disease, skin and muscle health, immune regulation, and kidney function, among others... [R]esearchers from Stanford University and Nanyang Technological University in Singapore used data from 108 participants between the ages of 25 and 75. Those participants donated blood and other biological samples (stool samples, oral and nasal swabs) every few months over the course of several years. From those samples, researchers were able to track age-related changes in more than 135,000 different molecules and microbes in the participants' bodies.

The analysis showed that the majority of molecules and microbes underwent major changes in their abundance (increasing or decreasing) during two time periods: when people were in their mid-40s and early 60s... The molecules that showed extreme changes in a person's 40s, for example, were related to alcohol, caffeine, and lipid metabolism, as well as cardiovascular disease and skin and muscle health. Meanwhile, molecular changes in a person's 60s were related to carbohydrate and caffeine metabolism, immune regulation, kidney function, cardiovascular disease, and skin and muscle health. According to experts, these changes might show up as a reduced ability to metabolize caffeine and alcohol, suggesting that it may be wise to cut back on those substances. People in their 40s and 60s may also see a greater risk of developing cardiovascular disease, and people in their 60s may benefit from supporting their immune systems.
The article ends with this advice from Dr. Ronald DePinho, a cancer biology professor at the University of Texas's cancer center: there's ways to manage or slow some of the changes associated with aging.

"The easiest way to do that is through lifestyle changes, said DePinho — that means staying active, eating and sleeping well, managing stress, and avoiding smoking and excessive alcohol."

"Sixty-six million years ago, all dinosaurs (except for birds) were wiped from the face of the Earth..." writes Gizmodo. "What's indisputable about this pivotal moment in Earth's history is that a 6.2 to 9.3-mile-wide (10 to 15-kilometer) asteroid struck what is now modern-day Mexico. Around the same time, however, volcanoes in what is now India experienced some of the largest eruptions in Earth's history."

Those volcanos "have long been proposed as an alternative cause for the demise of the dinosaurs..." writes Phys.org. But "Now, climate scientists from Utrecht University and the University of Manchester show that while the volcanism caused a temporary cold period, the effects had already worn off thousands of years before the meteorite impacted." Earth scientists have fiercely debated for decades whether a massive outpouring of lava on the Indian continent, which occurred both prior to and after the meteorite impact, also contributed to the demise of dinosaur populations roaming Earth. These volcanic eruptions released vast amounts of CO2, dust, and sulfur, thereby significantly altering the climate on Earth — but in different ways and on different timescales to a meteorite impact. The new publication provides compelling evidence that while the volcanic eruptions in India had a clear impact on global climate, they likely had little to no effect on the mass extinction of the dinosaurs.

By analyzing fossil molecules in ancient peats from the United States of America, the scientific team reconstructed air temperatures for the time period covering both the volcanic eruptions and the meteorite impact. Using this method, the researchers show that a major volcanic eruption occurred about 30,000 years before the meteor impact, coinciding with at least a 5 degrees Celsius cooling of the climate... Importantly, the scientists discovered that by around 20,000 years before the meteorite impact, temperatures on Earth had already stabilized and had climbed back to similar temperatures before the volcanic eruptions started.
The study is published in the journal Science Advances. And Gizmodo shares this quote from Bart van Dongen of The University of Manchester, who worked on the research.

"The study provides vital insights not only into the past but could also help us find ways for how we might prepare for future climate changes or natural disasters."

The world's first nuclear-powered battery — a diamond with an embedded radioactive isotope — could power small devices for thousands of years, according to scientists at the UK's University of Bristol.

Long-time Slashdot reader fahrbot-bot shared this report from LiveScience: The diamond battery harvests fast-moving electrons excited by radiation, similar to how solar power uses photovoltaic cells to convert photons into electricity, the scientists said.

Scientists from the same university first demonstrated a prototype diamond battery — which used nickel-63 as the radioactive source — in 2017. In the new project, the team developed a battery made of carbon-14 radioactive isotopes embedded in manufactured diamonds. The researchers chose carbon-14 as the source material because it emits short-range radiation, which is quickly absorbed by any solid material — meaning there are no concerns about harm from the radiation. Although carbon-14 would be dangerous to ingest or touch with bare hands, the diamond that holds it prevents any short-range radiation from escaping. "Diamond is the hardest substance known to man; there is literally nothing we could use that could offer more protection," Neil Fox, a professor of materials for energy at the University of Bristol, said in the statement...

A single nuclear-diamond battery containing 0.04 ounce (1 gram) of carbon-14 could deliver 15 joules of electricity per day. For comparison, a standard alkaline AA battery, which weighs about 0.7 ounces (20 grams), has an energy-storage rating of 700 joules per gram. It delivers more power than the nuclear-diamond battery would in the short term, but it would be exhausted within 24 hours. By contrast, the half-life of carbon-14 is 5,730 years, which means the battery would take that long to be depleted to 50% power....

[A] spacecraft powered by a carbon-14 diamond battery would reach Alpha Centauri — our nearest stellar neighbor, which is about 4.4 light-years from Earth — long before its power were significantly depleted.
The battery has no moving parts, according to the article. It "requires no maintenance, nor does it have any carbon emissions."

"Voyager 1 is currently exploring interstellar space at a distance of 15.5 billion miles (24.9 billion kilometers) away from Earth," writes Gizmodo.

And yet a team of amateur astronomers in the Netherlands was able to receive Voyager's signals on a 1950s-era telescope... The astronomers used orbital predictions of Voyager 1's position in space to correct for the Doppler shift in frequency caused by the motion of Earth, as well as the motion of the spacecraft through space... [The signal] was found live, and further analysis later confirmed that it corresponded to the position of Voyager 1.
"I did the experiment," mathematician/scientific software engineer Tammo Jan Dijkema told Slashdot in an email, as "one of a crew of four." He works at ASTRON (the Netherlands Institute for Radio Astronomy) while volunteering at the Dwingeloo radio telescope, and wants to clarify any suggestion in Gizmodo's article "that we received signals at S-band, which is not true. We received the 'normal' Voyager-1 signal at 8.4 GHz. See our blog post... The Dwingeloo reception was not related to Voyager's temporary glitch at all."

And Scientific American shares an interesting perspective on the Voyager probes: we everyday Earthlings may simplistically think of the sun as a compact distant ball of light, in part because our plush atmosphere protects us from our star's worst hazards. But in reality the sun is a roiling mass of plasma and magnetism radiating itself across billions of miles in the form of the solar wind, which is a constant stream of charged plasma that flows off our star. The sun's magnetic field travels with the solar wind and also influences the space between planets. The heliosphere grows and shrinks in response to changes in the sun's activity levels over the course of an 11-year cycle... [Jamie Rankin, a space physicist at Princeton University and deputy project scientist of the Voyager mission] notes, astronomers of all stripes are trapped within that chaotic background in ways that may or may not affect their data and interpretations. "Every one of our measurements to date, until the Voyagers crossed the heliopause, has been filtered through all the different layers of the sun," Rankin says.

On their trek to interstellar space, the Voyagers had to cross a set of boundaries: first a termination shock some seven billion or eight billion miles away from the sun, where the solar wind abruptly begins to slow, then the heliopause, where the outward pressure from the solar wind is equaled by the inward pressure of the interstellar medium. Between these two stark borders lies the heliosheath, a region where solar material continues to slow and even reverse direction. The trek through these boundaries took Voyager 1, the faster of the twin probes, nearly eight years; such is the vastness of the scale at play.

Beyond the heliopause is interstellar space, which Voyager 1 entered in 2012 and Voyager 2 reached in 2018. It's a very different environment from the one inside our heliosphere — quieter but hardly quiescent. "It's a relic of the environment the solar system was born out of," Rankin says of the interstellar medium. Within it are energetic atomic fragments called galactic cosmic rays, as well as dust expelled by dying stars across the universe's eons, among other ingredient.
Earlier this month Wired noted " The secret of the Voyagers lies in their atomic hearts: both are equipped with three radioisotope thermoelectric generators, or RTGs — small power generators that can produce power directly on board. Each RTG contains 24 plutonium-238 oxide spheres with a total mass of 4.5 kilograms..." But as time passes, the plutonium on board is depleted, and so the RTGs produce less and less energy. The Voyagers are therefore slowly dying. Nuclear batteries have a maximum lifespan of 60 years. In order to conserve the probes' remaining energy, the mission team is gradually shutting down the various instruments on the probes that are still active...

Four active instruments remain, including a magnetometer as well as other instruments used to study the galactic environment, with its cosmic rays and interstellar magnetic field. But these are in their last years. In the next decade — it's hard to say exactly when — the batteries of both probes will be drained forever.

Nature magazine reports that "A study that stoked enthusiasm for the now-disproven idea that a cheap malaria drug can treat COVID-19 has been retracted — more than four-and-a-half years after it was published." Researchers had critiqued the controversial paper many times, raising concerns about its data quality and an unclear ethics-approval process. Its eventual withdrawal, on the grounds of concerns over ethical approval and doubts about the conduct of the research, marks the 28th retraction for co-author Didier Raoult, a French microbiologist, formerly at Marseille's Hospital-University Institute Mediterranean Infection (IHU), who shot to global prominence in the pandemic. French investigations found that he and the IHU had violated ethics-approval protocols in numerous studies, and Raoult has now retired.

The paper, which has received almost 3,400 citations according to the Web of Science database, is the highest-cited paper on COVID-19 to be retracted, and the second-most-cited retracted paper of any kind....

Because it contributed so much to the HCQ hype, "the most important unintended effect of this study was to partially side-track and slow down the development of anti-COVID-19 drugs at a time when the need for effective treatments was critical", says Ole Søgaard, an infectious-disease physician at Aarhus University Hospital in Denmark, who was not involved with the work or its critiques. "The study was clearly hastily conducted and did not adhere to common scientific and ethical standards...."

Three of the study's co-authors had asked to have their names removed from the paper, saying they had doubts about its methods, the retraction notice said.
Nature includes this quote from a scientific-integrity consultant in San Francisco, California. "This paper should never have been published — or it should have been retracted immediately after its publication."

"The report caught the eye of the celebrity doctor Mehmet Oz," the Atlantic reported in April of 2020 (also noting that co-author Raoult "has made news in recent years as a pan-disciplinary provocateur; he has questioned climate change and Darwinian evolution...")

And Nature points out that while the study claimed good results for the 20 patients treated with HCQ, six more HCQ-treated people in the study actually dropped out before it was finished. And of those six people, one died, while three more "were transferred to an intensive-care unit."

Thanks to Slashdot reader backslashdot for sharing the news.

sciencehabit shares a report from Science Magazine: With a few keystrokes, anyone can ask an artificial intelligence (AI) program such as ChatGPT to write them a term paper, a rap song, or a play. But don't expect William Shakespeare's originality. A new study finds such output remains derivative -- at least for now. [...] [O]bjectively testing this creativity has been tricky. Scientists have generally taken two tacks. One is to use another computer program to search for signs of plagiarism -- though a lack of plagiarism does not necessarily equal creativity. The other approach is to have humans judge the AI output themselves, rating factors such as fluency and originality. But that's subjective and time intensive. So Ximing Lu, a computer scientist at the University of Washington, and colleagues created a program featuring both objectivity and a bit of nuance.

Called DJ Search, it collects pieces of text of a minimum length from whatever the AI outputs and searches for them in large online databases. DJ Search doesn't just look for identical matches; it also scans for strings whose words have similar meanings. To evaluate the meaning of a word or phrase, the program itself relies on a separate AI algorithm that produces a set of numbers called an "embedding," which roughly represents the contexts in which words are typically found. Synonymous words have numerically close embeddings. For example, phrases that swap "anticipation" and "excitement" are considered matches. After removing all matches, the program calculates the ratio of the remaining words to the original document length, which should give an estimate of how much of the AI's output is novel. The program conducts this process for various string lengths (the study uses a minimum of five words) and combines the ratios into one index of linguistic novelty. (The team calls it a "creativity index," but creativity requires both novelty and quality -- random gibberish is novel but not creative.)

The researchers compared the linguistic novelty of published novels, poetry, and speeches with works written by recent LLMs. Humans outscored AIs by about 80% in poetry, 100% in novels, and 150% in speeches, the researchers report in a preprint posted on OpenReview and currently under peer review. Although DJ Search was designed for comparing people and machines, it can also be used to compare two or more humanmade works. For example, Suzanne Collins's 2008 novel The Hunger Games scored 35% higher in linguistic originality than Stephenie Meyer's 2005 hit Twilight. (You can try the tool online.)

Axiom Space has revised its plan for assembling its commercial space station by launching the Payload, Power, and Thermal module first, enabling it to operate as a free-flying platform as early as 2028 -- two years ahead of the original timeline. Space.com reports: NASA awarded Axiom Space a contract in 2020 to attach one or more modules to the International Space Station (ISS), which is set to retire by 2030 at the earliest. The original plan called for Axiom to detach a multi-module group from the ISS, creating a commercial outpost in low Earth orbit that will continue operating after the ISS is gone. But that plan has now been altered.

To create its space station, Axiom plans to launch five modules: a payload/power/thermal element, an airlock, a research/manufacturing hub, and a pair of habitat modules. The original plan was for Axiom to launch the Habitat 1 module to the ISS first, followed by the additional elements. The new assembly sequence will see the Payload, Power and Thermal module launch to the ISS first. This module could detach from the station -- and become a free flyer called Axiom Station -- as soon as 2028, according to the company. After that happens, Axiom will continue assembling the outpost, launching the Habitat 1 module to meet up with it. Habitat 1 will be followed by the airlock, the Habitat 2 module, and then the research and manufacturing facility. Angela Hart, a manager for the Commercial Low Earth Orbit Development Program at NASA's Johnson Space Center in Houston, said: "The updated assembly sequence has been coordinated with NASA to support both NASA and Axiom Space needs and plans for a smooth transition in low Earth orbit."

NASA's Parker Solar Probe will make its closest approach yet to the Sun on Christmas Eve, flying within 3.8 million miles of the solar surface and entering its atmosphere for the first time.

The spacecraft, which travels at speeds up to 430,000 miles per hour, aims to study the origins of solar wind -- the stream of charged particles emanating from the Sun's corona. The probe's heat shield will endure temperatures exceeding 2,500-degree Fahrenheit during the flyby, requiring specialized materials like sapphire crystal tubes and niobium wiring to protect its instruments.

Ars Technica's Eric Berger reports: In a wide-ranging interview with a Russian television station, the chief executive of Russia's main space corporation said the country is now planning to participate in the International Space Station project all the way to NASA's desired goal of 2030. "In coordination with our American colleagues, we plan to de-orbit the station sometime around the beginning of 2030," the country's chief space official, Yuri Borisov, said during the interview. "The final scenario will probably be specified after the transition to a new NASA administration."

While the documents for such an extension have not been signed, these comments appear to represent a change in tone from Russia. When he first became head of Roscosmos in 2022, Borisov said Russia would leave the station partnership "after" 2024, which was interpreted as shortly thereafter. Later, Russia committed to working with NASA to keep the orbital outpost flying only through 2028. The US space agency has expressed a consistent desire to keep flying the station until 2030, after which point it hopes that private space station operators can provide one or more replacement facilities.
Borisov said the aging station, elements of which have now been in space for more than a quarter of a century, are becoming difficult to maintain. "Today our cosmonauts have to spend more time repairing equipment and less and less time conducting experiments," he said. Borisov also discussed Russia's challenges of getting private investment in space-related activities, saying: "In the West, particularly in America, 70 percent of space services are provided by satellite constellations created by private companies. This process has only just begun with us. This is a very risky business for potential investors."

"Right now, the dynamic growth of private space is being influenced by the general economic situation (likely referring to Russia's costly war in Ukraine), high inflation and interest rates, which leads to expensive money for private investors. We can hope that this will be a temporary period and more favorable times will come soon."

An anonymous reader quotes an opinion piece from The Guardian, written by Prof Mark Pallen and Dr Aimee Parker (Quadram Institute, Norwich), Prof Nick Loman (University of Birmingham), Prof Alan Walker (University of Aberdeen): Contrary to what is implied in [this article], the weight of expert opinion in medical microbiology rejects the existence of a "brain microbiome" in the sense of a resident microbial community in healthy human brains. While pathogenic microbes -- such as Borrelia burgdorferi, which causes Lyme disease, or fungal pathogens like Cryptococcus neoformans -- can invade the brain and cause neurological symptoms, these are examples of infections, not evidence of a native microbial community.

Similarly, cognitive benefits of vaccines can be explained by their role in preventing infections or modulating immune responses and inflammation, rather than any impact on a "brain microbiome." Furthermore, the studies cited in the article have not undergone independent validation, nor do they provide any kind of consistent picture. This mirrors controversies around other supposed microbiomes -- such as that of the placenta -- which have failed to withstand independent scrutiny. Over a decade of research indicates that contamination, typically from laboratory reagents, is the most plausible explanation for such findings, particularly when even supposedly ultrapure water has been shown to harbor DNA signatures and culturable microbes.

If diverse microbes are truly abundant in the brain, why have they not been repeatedly and consistently cultured in over a century and a half of medical microbiology? Why have they not been observed in numerous microscopy studies of human brain tissue? Efforts to explore overlooked roles of microbes in neurological conditions are welcome, but they must be grounded in robust and reproducible science -- not speculative discussion of a "brain microbiome." In the article mentioned above, author Amy Fleming discusses the emerging research connecting infections such as Borrelia, Cryptococcus, and herpes viruses to reversible dementia, challenging the long-held belief that the brain is sterile.

She highlights the Alzheimer's Pathobiome Initiative, which investigates how brain infections may contribute to diseases like Alzheimer's, with the goal of developing new diagnostic tools and treatments. Vaccines like BCG and zoster have shown protective effects, while good hygiene, oral health, and a healthy lifestyle can help reduce risks.

The publisher of a high-profile, now-corrected study on black plastics has been removed from a critical index of academic journals amid questions about quality criteria, according to a report by Retraction Watch. From a report: On December 16, Clarivate -- a scholarly publication analytics company -- removed the journal Chemosphere from its platform, the Web of Science, which is a key index for academic journals. The indexing platform tracks citations and calculates journal "impact factors," a proxy for relevance in its field. It's a critical metric not only for the journals but for the academic authors of the journal's articles, who use the score in their pursuit of promotions and research funding.

To be included in the Web of Science, Clarivate requires journals to follow editorial quality criteria. According to Retraction Watch, Chemosphere has retracted eight articles this month and published 60 expressions of concern since April. In a December 12 news release, Chemosphere acknowledged the quality concerns and laid out steps it will take to improve its editorial process. Those include improvements to article vetting and peer review, along with assurances that articles will be retracted if there's evidence of policy breaches. "We believe that these measures will help us regain the standard of research integrity that has always been so important to us," the news release stated.

NASA has delayed the launch of SpaceX Crew-10 to late March 2025 to allow time for processing a new Dragon spacecraft, extending the stay of astronauts Butch Wilmore and Suni Williams on the ISS to about nine months. CNN reports: Williams and Wilmore launched to space in June, piloting the first crewed test flight of Boeing's Starliner spacecraft. Their trip, expected to last about a week, ballooned into a monthslong assignment after their vehicle experienced technical issues en route to the space station and NASA determined it would be too risky to bring them home aboard the Starliner.

The astronauts have since joined Crew-9, a routine space station mission originally slated to return to Earth no earlier than February after a handoff period with Crew-10. Now, Crew-10 will get off the ground at least a month later than expected because NASA and SpaceX teams need "time to complete processing on a new Dragon spacecraft for the mission," according to the space agency. "NASA and SpaceX assessed various options for managing the next crewed handover, including using another Dragon spacecraft," NASA noted in a blog post on Tuesday. "After careful consideration, the team determined that launching Crew-10 in late March, following completion of the new Dragon spacecraft, was the best option for meeting NASA's requirements and achieving space station objectives for 2025."